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Assistant Professor
Department of Microbiology, Biochemistry and Immunology
Morehouse School of Medicine
Hugh Gloster Building, Suite 332
720 Westview Dr., SW
Atlanta, GA 30310-1495
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- Adjunct Scientist, The Boston Biomedical Research Institute (BBRI), Watertown, MA
- Associate Scientist, Vincent Center for Reproductive Biology (VCRB), Massachusetts General Hospital, Boston, MA
- Affiliate Scientist, Cooperative Reproductive Science Research Center (CRSCR), Morehouse School of Medicine, Atlanta, GA
- University of Havana, Cuba; and
- Institut National des Scienses Appliquees (INSA) Toulouse, France
- PhD, Enzymology & Microbiology, 1985
- University of Havana, Cuba, Pharmaceutical Biochemistry, 1973
Research Interests:
Dr. Gonzalez’ research has both basic science and translational importance.
His laboratory’s research interest centers on:
- The biological effects of cytokines and growth factors in cancer.
- The role of leptin (a major adipocytokine secreted by adipose and cancer tissues) in the development of cancer
Ongoing lab research projects include:
- Unraveling the mechanisms of leptin angiogenic effects in breast cancer
- Involvement of leptin and IL-1 signaling in breast cancer progression
- Role of obesity and leptin signaling in the progression of carcinogenic-induced breast cancer.
- Targeting the HER2/neu and leptin signaling link in breast cancer
- Combined chemoprevention of breast cancer with tamoxifen and leptin antagonists
- Role of leptin signaling in endometrial cancer.
These investigations will take Dr. Gonzalez a step closer to translational use of leptin antagonists (LPrAs; developed in his lab) as co-adjuvant drugs for cancer chemoprevention/treatment, particularly for obese and post-menopausal women who show higher incidence of breast cancer and levels of leptin.
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